Optimally, clinical specimens should be obtained before antimicrobial therapy commences in order to avoid loss of viability of the etiological agents. Treatment of the patient, however, should not be delayed while awaiting collection of specimens or results from the laboratory and a specimen should be obtained in all suspect cases as bacterial pathogens can still be detected even after antimicrobial therapy has begun.
They are more reliably isolated if the clinical specimens are examined as soon as possible after collection. Cerebrospinal fluid CSF should be processed in a microbiology laboratory within 1 hour after collection or inoculated into Trans-Isolate T-I medium for transport to the laboratory if processing within 1 hour is not feasible. Blood specimens should be immediately inoculated into a blood culture bottle and transported to a microbiology laboratory as soon as possible for overnight incubation and growth of bacteria.
Figure 5 describes how to collect blood from an arm by applying a tourniquet, selecting a vein, and preparing the proposed puncture site. Top of Page. Skip directly to site content Skip directly to page options Skip directly to A-Z link.
Section Navigation. Facebook Twitter LinkedIn Syndicate. Chapter 5: Collection and Transport of Clinical Specimens. Minus Related Pages. Printer friendly version pdf icon [11 pages] The proper collection and transport of clinical specimens is critical for the isolation, identification, and characterization of agents that cause bacterial meningitis.
Biosafety It is important to adhere to proper biosafety guidelines while handling potentially infectious clinical specimens in order to maintain a safe working environment for patients, health care workers, and laboratorians. Infection may be transmitted from patient to staff and from staff to patient during the procedures described below. In addition to the agents that cause bacterial meningitis, the patient could have other bacterial or viral agents in either the CSF of blood and both are a great hazard and potentially lethal.
The ventricles are shown in blue on the following midsagittal section of the brain. The Ventricles CSF is produced mainly by a structure called the choroid plexus in the lateral, third and fourth ventricles. CSF flows from the lateral ventricle to the third ventricle through the interventricular foramen also called the foramen of Monro. The third ventricle and fourth ventricle are connected to each other by the cerebral aqueduct also called the Aqueduct of Sylvius.
CSF then flows into the subarachnoid space through the foramina of Luschka there are two of these and the foramen of Magendie only one of these. Absorption of the CSF into the blood stream takes place in the superior sagittal sinus through structures called arachnoid villi.
For general information, Learn About Clinical Studies. At the time of the LP it will already be determined if the subject is able to give informed consent and if not a legally authorized representative will have been appointed who will decide if the additional CSF and plasma can be obtained from the individual.
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Save this study. Warning You have reached the maximum number of saved studies Cerebrospinal Fluid Collection and Repository Storage The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Listing a study does not mean it has been evaluated by the U. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Last Update Posted : September 13, See Contacts and Locations.
Study Description. Background: - Cerebrospinal fluid CSF is the liquid around the brain and spinal cord. Objectives: - To collect cerebrospinal fluid and blood samples from individuals who are having a lumbar puncture. Eligibility: - Individuals between 2 and years of age who are scheduled to have a lumbar puncture for clinical or research purposes. Design: Participants will have a lumbar puncture for clinical or research purposes.
During the procedure, an additional sample of CSF will be collected. They will also provide a blood sample, if one is not taken at the time of the procedure. Treatment will not be provided as part of this study.
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